Vincent Dive

Dr V. Dive is the head of the “Section of Molecular Engineering of Proteins” at the CEA Life Science Division in Saclay and the leader of a group which has a long-standing expertise in the chemistry of phosphorus-containing peptides as potent inhibitors of zinc-metalloproteinases and evaluation of their in vivo activity. Labelling of inhibitors with ³H and ¹⁴C in combination with digital autoradiography is routinely used to study the in vivo biodistribution of corresponding compounds. Dr. Dive’s group has been involved in multiple European integrated projects (FP4, FP5, FP6 and FP7) dealing with the development of inhibitors of zinc proteases (MMPs, ACE, ACE2) for cancer and cardiovascular applications. The group has published more than 100 peer-reviewed articles and 8 patents on protease inhibitors. The team has been selected in 2011, as a member of the “Laboratory of Excellence in Research on Medication and Innovative Therapeutics” (LERMIT). (http://www.cea.fr/drf/ibitecs/Pages/services/simopro.aspx and www.labex-lermit.fr)