Beyond Cancer Genomes. Barcelona Conference on Epigenetics and Cancer

#BCEC2016

Beyond Cancer Genomes. Barcelona Conference on Epigenetics and Cancer

13th and 14th October 2016

CosmoCaixa Barcelona. C/ Isaac Newton, 26. Barcelona

Scientific leaders

Eduard Batlle
Salvador Aznar-Benitah
Raúl Méndez
Institute for Research in Biomedicine Barcelona, ICREA. BIST

Poster

beyond_cancer_a0.jpg

Program

bdebate_bcec_dossier2.pdf

Synopsis

sinopsisbdebate_bcec2016_en.pdf

Tabs

Description

Over the past few years, the genomes and transcriptomes of thousands of tumors have been sequenced. This information has revealed an enormous diversity of tumor genotypes and it is helping personalize the treatments of cancer patients. However, despite these advances, it remains a major challenge to predict fundamental aspects of tumor cell behavior such as resistance to therapy or metastatic dissemination.

This debates, organized by B·Debate, an initiative of Biocat and "la Caixa" Foundation, and the Institute for Research in Biomedicine of Barcelona (IRB Barcelona), with the collaboration of Molecular Biology Institute of Barcelona (IBMB,CSIC), Institut de Medicina Predictiva i Personalitzada del Càncer (IMPPC), Cancer Epigenetics and Biology Program (PEBC; IDIBELL) and the Center for Genomic Regulation (CRG) aim to gather world-leading experts in the fields of epigenetic regulation, RNA processing and translation, stem cell biology or tumor microenvironment to discuss how the information contained within the cancer genomes is being integrated with temporal and spatial gene regulation mechanisms to understand the complex cellular reprograming associated to cancer progression.

Agenda

Thursday, October 13th, 2016
9:00	Welcome
9:15	SESSION 1: Epigenetic Control of Cell States Chair: Luciano di Croce (CRG, Barcelona)
9:15	Gene regulation dynamics in stem cell and cancer Luciano di Croce (CRG, Barcelona)
9:50	Cancer: the view from chromosome neighborhoods Rick Young (Whitehead Institute. Cambridge, MA, USA)
10:25	Short talk from selected abstracts
10:45	Chromatin during epithelial to mesenchymal transition Sandra Peiró (IMIM, Barcelona)
11:20	Coffee break
11:50	SESSION 2: Stem Cells and Cancer Chair: Michaela Frye (Cambridge Stem Cell Institute (CSCI), UK)
11:50	Epigenetic mechanisms governing stem cell function in homeostasis and cancer Salvador Aznar Benitah (IRB Barcelona, Barcelona)
12:25	Short talk from selected abstracts
12:45	Understanding epidermal cell plasticity Giacomo Donati (Center for Stem Cells and Regenerative Medicine. King’s College London, UK)
13:20	RNA modifications in the stress responses and cancer Michaela Frye (Cambridge Stem Cell Institute (CSCI), UK)
13:55	Lunch and poster session
15:25	SESSION 3: Regulation of RNA functions in Cancer Chair: Juan Valcárcel (CRG), Barcelona)
15:25	Translating the Cancer Genome One Codon at a Time and its Therapeutic Implications Davide Ruggero (University of San Francisco (USCF), CA, USA)
16:00	Short talk from selected abstracts
16:20	RNA-binding proteins in cancer Raúl Méndez (IRB Barcelona, Barcelona)
16:55	Coffee break
17:25	Networks of alternative splicing regulation in cancer Juan Valcárcel (CRG), Barcelona)
18:00	Oncogenic splicing factors in breast-cancer pathogenesis Adrian Krainer (Cold Spring Harbor Laboratory (CSHL), NY, USA)
18:35	Short talk from selected abstracts
18:55	Poster session and networking

Friday, October 14th, 2016
9:00	SESSION 4: Oncogenic and Non-oncogenic Addictions in Cancer Chair: Laura Soucek (VHIO, Barcelona)
9:00	Myc functions in stem cells and cancer Andreas Trumpp (German Cancer Research Center (DKFZ). Heidelberg) Germany
9:35	Exploring and exploiting aberrant cell fate programs in leukemia Johannes Zuber (Research Institute of Molecular Pathology (IMP), Vienna, Austria)
10:10	The contribution of genomic instability to malignant growth in Drosophila Cayetano González (IRB Barcelona, Barcelona)
10:45	Coffee break
11:15	SESSION 5: Modeling cancer therapeutics Chair: Laura Soucek (VHIO, Barcelona)
11:15	New first-in-class anti-Myc therapeutics Laura Soucek (VHIO, Barcelona)
11:50	A p53-dependent checkpoint limits the viability of mammalian haploid cells Oscar Fernández Capetillo (CNIO, Madrid)
12:25	Short talk from selected abstracts
12:45	A stromal gene program drives metastasis in colorectal cancer Eduard Batlle (IRB Barcelona, Barcelona)
13:20	Lunch
14:50	SESSION 6: Mining genomics to understand cancer Chair: Oscar Fernández Capetillo (CNIO, Madrid)
14:50	Long-lasting trans-generational epigenetic memory of environmental change Ben Lehner (CRG, Barcelona)
15:25	The genomic landscape of chronic lymphocytic leukemia: functional role of coding and non-coding mutations Carlos López Otín (Universidad de Oviedo, Oviedo)
16:00	Short talk from selected abstracts
16:20	Linking stemness properties to therapy failure and disease recurrence John Dick (University Health Network , Toronto, Canada)
16:55	Closing remarks

All sessions will be held in English

Speakers

Salvador Aznar Benitah

Group Leader, Stem cells and cancer, Institute for Research in Biomedicine (IRB Barcelona)

Eduard Batlle

Institut de Recerca Biomèdica de Barcelona (IRB)

Raúl Méndez

Group Leader, Translational control of cell cycle and differentiation, Institute for Research in Biomedicine (IRB Barcelona)

Luciano di Croce

Group Leader, Gene regulation, stem cells and cancer, Centre for Genomic Regulation (CRG)

Richard A. Young

Professor of Biology, MIT, Whitehead Institute

Michaela Frye

Stem Cell Homeostasis and Disease, Cambridge Stem Cell Institute (CSCI)

Davide Ruggero

Professor

Juan Valcárcel

Group Leader, Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG)

Adrian Krainer

Professor Harvard University, Cold Spring Harbor Laboratory

Andreas Trumpp

Professor, German Cancer Research Center (DKFZ)

Johannes Zuber

Group Leader, Research Institute of Molecular Pathology (IMP)

Cayetano González

Group Leader, Cell division laboratory, Institute for Research in Biomedicine (IRB Barcelona)

Laura Soucek

Principal Investigator of Mouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO)

Oscar Fernández Capetillo

Centro Nacional de Investigaciones Oncológicas (CNIO)

Ben Lehner

Group Leader, Genetic Systems, Center for Genomic Regulation (CRG)

Carlos López

Department of Bioquimics and Molecular Biology, Universidad de Oviedo

John Dick

Professor, University of Toronto

Sandra Peiró

Hospital del Mar Medical Research Institute (IMIM)

Giacomo Donati

University of Turin & Human Genetics Foundation (HuGeF)

Travel & Venue

Address

CosmoCaixa Barcelona

C/ Isaac Newton, 26. Barcelona (Spain)

How to arrive

L7 (Ferrocarrils de la Generalitat), Av. Tibidabo

H4, V13, V15, 22, 73, 75, 60, 196

Synopsis

Cancer beyond the genome

Nowadays there are very few doubts as to the fundamental role genes play in the onset and spread of cancer. Nevertheless, just reading the letters they are made up of doesn't seem to be enough to fully understand it. A group of top experts from around the world came together on 13 and 14 October 2016 to discuss some of the latest, most important advances in this arena.